12/7/2023 0 Comments Deep sleep diabetes remedy pdfshowed that the insulin response to an oral glucose challenge was higher when comparing the total sleep deprivation condition to the normal sleep condition, suggesting an insulin resistant state that is induced by acute sleep deprivation. Furthermore, there is increase in circulating levels of ghrelin, hunger-promoting hormone as well a decrease in leptin, which is a satiety factor. Orexin system is overactive during sleep deprivation which along with over activity of sympathetic nervous system leads to overfeeding. One of the important mechanisms linking weight gain with sleep deprivation is likely hyperactivity of orexin system. Sleep disturbance are associated with dysregulation of the neuroendocrine control of appetite. M ECHANISM OF O BESITY AND G LYCEMIC D YSREGULATION WITH S LEEP D ISTURBANCES The authors concluded that sleep disturbances should therefore be systematically considered in guidelines for the screening as well as while making preventive strategies for T2DM. Similarly, the risk of developing T2DM associated with insufficient (≤5 h/day) or excessive sleep duration (≥9 h/day) or performing shift work was comparable to that of being physically inactive. Difficulty initiating sleep increased the risk of T2DM by 55%, while difficulty maintaining sleep increased its risk by 74%. After adjustment for confounders, the risk of developing diabetes due to OSA, difficulty maintaining or initiating sleep was slightly less than the risk of having a family history of diabetes but greater than that of being physically inactive. The categories of sleep disturbances that contribute to obesity and T2DM include the following: (1) alterations of sleep duration, chronic sleep restriction, and excessive sleep (2) alterations in sleep architecture (3) sleep fragmentation (4) circadian rhythm disorders and disruption (i.e., shift work) and (5) OSA.Ī recent systematic review and meta-analysis demonstrated sleep disturbances as significant risk factors for diabetes with effect sizes similar to those imparted by traditional risk factors. Studies have also reported higher risk of obesity and T2DM in individuals with long sleep duration (≥9 h/day) also. S LEEP D ISTURBANCES AND R ISK OF O BESITY AND T YPE 2 D IABETES M ELLITUSĮpidemiological data have suggested higher risk of obesity and T2DM in individuals with shorter sleep duration (<5–6 h/night) as well as those of poor sleep quality.
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